Additional Info:
For patients 6 years and older.
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥4 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86255).
If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <47 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) and Gliadin (Deamidated) Antibody (IgG) will be performed at an additional charge (CPT code(s): 83516).
Useful For: Celiac disease is characterized by the presence of Gliadin Antibody. Such patients display a hypersensitivity to gluten (wheat) in their diet. The antibody is undetectable when patients with hypersensitivity are placed on gluten-free diets. Antibody IgA is more specific and IgG is more sensitive to Celiac Disease.
Tissue Transglutaminase Antibody, IgA is useful in diagnosing gluten-sensitive enteropathies, such as celiac sprue, and an associated skin condition, dermatitis herpetiformis.
Methodology: Immunoassay (IA) • Immunoturbidimetric Assay
Specimen Requirements: 1 yellow-top SST tube (minimum: 1.0 mL of serum). Centrifuge SST 30 minutes after draw. Refrigerate specimen after collection.
NOTE: Grossly hemolyzed specimens are unacceptable. Avoid lipemia.
Analytical Time:
3 – 6 days
Days Set Up: No set up days
CPT Information:
82784
83516 x 3 gliadin IgA, IgG; tTG IgA 86255 reticulin Ab, IgA